INTELLIGENCE
/ ChemGrade Journal
/ Critical Analysis of Biochemical Compounds
Tongkat Ali: Estandarización de Eurycomanone
Why "100:1" extract ratios are marketing fraud. The clinical necessity of 2% Eurycomanone for Leydig cell stimulation.
Fadogia Agrestis: The Toxicity Profile
Analyzing the renal and hepatic cytotoxicity risks associated with high-dose Fadogia use.
Free Testosterone Index vs. Total Serum
Why Total T is a vanity metric. Understanding albumin and SHBG binding affinity.
Zinc Picolinate vs. Citrate for Leydig Cells
Optimizing intra-testicular zinc concentrations for steroidogenesis.
Boron Cycling for Estrogen Management
The 2-week cycling protocol to lower SHBG and prevent estrogen rebound.
Cortisol-Testosterone Ratio Optimization
Mitigating catabolic states via Phosphatidylserine and HPA Axis modulation.
Natural Aromatase Modulation (DIM)
Indole-3-Carbinol pathways for healthy estrogen metabolism.
Turkesterone Anabolic Index: Hype vs. Data
Ecdysteroid efficacy vs. placebo: Analyzing the human data gap.
Ashwagandha KSM-66 for Hypertrophy
Impact on strength output, recovery velocity, and muscle size.
SHBG Binding Affinity Inhibitors
Stinging Nettle Root and its role in freeing bound androgens.
Vías de Síntesis de Colágeno Dérmico
Beyond "Beauty": The mechanism of fibroblast activation via hydrolyzed peptide signaling.
Inositol Protocols for Insulin Sensitivity
Myo-Inositol vs D-Chiro-Inositol ratios (40:1) for ovarian function restoration.
Berberine vs. GLP-1 Agonists
Analyzing the "Natural Ozempic" claims: AMPK activation vs. GLP-1 secretion.
Estrogen Dominance Clearance Protocols
Supporting Phase I & II liver detoxification pathways with DIM and Calcium D-Glucarate.
Post-Natal Hair Density Restoration
Addressing the Telogen Effluvium shift post-pregnancy via Iron and Keratin precursors.
Perimenopausal Magnesium Deficiency
Symptom management: Hot flashes, insomnia, and bone density preservation.
Iron Bisglycinate Bioavailability
Ferritin restoration protocols without gastrointestinal distress.
Visceral Adipose Tissue Mobilization
Combating the estrogen-drop metabolic shift from subcutaneous to visceral storage.
Thyroid T4 to T3 Conversion Cofactors
Why normal TSH doesn't mean normal metabolism. The role of Selenium and Zinc.
L. Crispatus for Vaginal Microbiome
Restoring pH balance and preventing dysbiosis naturally.
Acetylcholine Precursors for Working Memory
Alpha-GPC vs. Choline Bitartrate: The blood-brain barrier transport problem.
Caffeine Half-Life & Adenosine Clearance
Why you crash: The receptor downregulation mechanism and timing optimization.
Lion's Mane & Nerve Growth Factor (NGF)
Hericenones and Erinacines: The distinction between fruiting body and mycelium.
Creatine for Sleep Deprived Cognition
Restoring cerebral phosphocreatine levels during fatigue states.
Alpha-GPC: Blood Brain Barrier Transport
Why Choline Bitartrate fails to enhance cognitive output.
Phosphatidylserine for Cortisol Blunting
Mitigating post-exercise stress and "wired but tired" insomnia.
Rhodiola Rosea for Mental Fatigue
Salidroside mechanism in burnout prevention and neurotransmitter preservation.
Modafinil Alternatives: Theacrine
Non-habituating stimulants for sustained focus without the crash.
Bacopa Monnieri & Synaptic Communication
Dendritic branching and long-term memory formation mechanisms.
AMPK Activation Pathways
Fasting mimetics and the metabolic master switch for cellular cleanup.
Omega-3 Index & All-Cause Mortality
Why "Fish Oil" isn't enough. The importance of the Erythrocyte EPA/DHA percentage.
NAD+ Safety: NMN vs. NR
Comparative bioavailability and the methylation concern.
Glutathione Recycling Cofactors
NAC + Glycine: Restoring the master antioxidant via rate-limiting precursors.
Glycemic Index vs. Insulin Load
Why "Low GI" is not enough for metabolic flexibility. The dairy paradox.
Mitochondrial Uncoupling Agents
Thermogenesis and caloric inefficiency: Creating a "proton leak" safely.
Resveratrol & Sirtuin Gene Activation
Mimicking caloric restriction pathways and solving the bioavailability crisis.
Apigenin & CD38 Inhibition
Preserving NAD+ levels by inhibiting the enzymatic "leak".
Visceral Fat Oxidation Rate
Mobilizing stubborn adipose tissue via catecholamines and Zone 2 training.
Electrolyte Osmolarity for Fasting
Preventing the "Fasting Flu" and refeeding syndrome.
Glycine & Core Body Temperature
Inducing sleep onset via peripheral vasodilation and thermoregulation.
Magnesium Threonate BBB Permeability
Why oxide and citrate fail the brain. The only magnesium that crosses the Blood-Brain Barrier.
Apigenin & Sleep Spindle Density
Enhancing memory consolidation and sedating the brain via GABA-A modulation.
Melatonin Micro-Dosing (0.3mg)
Why less is more: Mimicking physiological secretion vs. pharmacological overdose.
Circadian Entrainment Triggers
Manipulating Light, Food, and Temperature (Zeitgebers) to anchor your rhythm.
GABA Receptor Allosteric Modulators
How Valerian and Lemon Balm mimic Benzodiazepines safely.
Adenosine Receptor Antagonists
Clearing sleep pressure: The biochemistry of wakefulness and caffeine withdrawal.
Slow Wave Sleep (Deep Sleep) Enhancers
Optimizing the restorative phase of the ultradian cycle.
The REM Rebound Effect
Consequences of alcohol and cannabis on sleep architecture.
L-Theanine Alpha Wave Induction
Promoting relaxation without sedation via frequency modulation.
Ashwagandha & Anhedonia: The Clinical Reality
Investigating the link between chronic Cortisol suppression and emotional blunting.
L-Tyrosine: Catecholamine Synthesis & Dopamine Upregulation
The rate-limiting precursor for Dopamine and Norepinephrine restoration under stress. How to use it, when it works, and when it does not.