Resveratrol & Sirtuin Gene Activation

The "French Paradox" Molecule

Resveratrol is a polyphenol found in red wine that acts as a caloric restriction mimetic. Its primary mechanism is the activation of SIRT1, a "longevity gene" that repairs DNA and improves mitochondrial efficiency. However, the hype often ignores the chemistry.

The Bioavailability Crisis

Standard Resveratrol is practically insoluble in water. If you swallow a capsule of dry powder, almost none of it enters your bloodstream. It requires two things to work:

• Trans-Isomer: You must use Trans-Resveratrol. The Cis-isomer is biologically inert.
• Fat Matrix: It must be consumed with a fat source (yogurt, olive oil) to trigger bile release and absorption.