Sleep Optimization Protocols
Deep sleep is where testosterone is produced, memories are consolidated, and cellular repair occurs. Compromising it compounds every other health variable.
Mechanism Overview
Sleep architecture is governed by GABA (inhibitory), adenosine (sleep pressure), and melatonin (circadian). Effective sleep compounds work on one or more of these pathways without suppressing REM architecture.
Recommended Foundation Stack
The clinical gold standard stack: Magnesium Glycinate (400mg) + Apigenin (50mg) taken 60 minutes before bed. Both compounds address different mechanisms — Magnesium via GABA-A modulation, Apigenin via benzodiazepine receptor partial agonism.
Track: HRV (Heart Rate Variability), REM duration via Oura or Whoop, morning cortisol.
All Protocols — Ranked by Efficacy Score
Frequently Asked Questions
What is the best supplement for deep sleep?
Magnesium Glycinate has the strongest clinical evidence for improving sleep quality, specifically slow-wave (deep) sleep duration. It is the recommended foundation of any sleep protocol.
Can I take Magnesium and Apigenin together?
Yes. They work on complementary mechanisms and do not interact negatively. This combination is the core of the ChemGrade sleep protocol.
Does L-Theanine help with sleep?
L-Theanine primarily reduces anxiety and promotes alpha brainwave states. It is more effective as a sleep-onset aid (reducing pre-sleep rumination) than for improving sleep depth.
Other Goal Protocols
* Clinical protocols are for educational purposes only. ChemGrade does not provide medical advice. Consult a physician before beginning any supplementation protocol.