Apigenin & CD38 Inhibition
Plugging the Leak
Everyone focuses on boosting NAD+ (using NMN or NR), but few focus on why it's declining. As we age, an enzyme called CD38 becomes overactive. CD38 is a "NAD+ Eater"—it aggressively destroys NAD+ molecules.
Taking NMN without inhibiting CD38 is like pouring water into a leaking bucket. You are boosting production, but the destruction rate is still too high.
The Apigenin Synergist
Apigenin (found in dried parsley and chamomile) is a potent CD38 inhibitor. By suppressing CD38 activity, it allows your natural (or supplemented) NAD+ levels to rise and remain stable. This makes it the perfect "Sidekick" to any longevity stack.
The Longevity Stack
Take 50mg - 100mg Apigenin at night (it also aids sleep) alongside your morning NMN. This attacks the NAD+ problem from both ends: Supply and Preservation.
Clinical Context
This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.
View Protocol