CHEMGRADE
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LONGEVITYCELLULARNAD

Apigenin & CD38 Inhibition

2025-03-15//READ: 4 MIN//BY CHEMGRADE RESEARCH

Plugging the Leak

Everyone focuses on boosting NAD+ (using NMN or NR), but few focus on why it's declining. As we age, an enzyme called CD38 becomes overactive. CD38 is a "NAD+ Eater"—it aggressively destroys NAD+ molecules.

Taking NMN without inhibiting CD38 is like pouring water into a leaking bucket. You are boosting production, but the destruction rate is still too high.

The Apigenin Synergist

Apigenin (found in dried parsley and chamomile) is a potent CD38 inhibitor. By suppressing CD38 activity, it allows your natural (or supplemented) NAD+ levels to rise and remain stable. This makes it the perfect "Sidekick" to any longevity stack.

The Longevity Stack

Take 50mg - 100mg Apigenin at night (it also aids sleep) alongside your morning NMN. This attacks the NAD+ problem from both ends: Supply and Preservation.

* This analysis is for educational purposes only. ChemGrade does not provide medical advice.

Clinical Context

This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.

View Protocol