Fadogia Agrestis: The Toxicity Profile
Introduction
Popularized by modern health podcasts, Fadogia Agrestis has surged in demand as a potent LH mimetic. While anecdotal reports of testicular size increase and libido are common, the safety profile remains questionable compared to established compounds like Tongkat Ali.
The Toxicology Concern
Unlike Tongkat Ali, Fadogia lacks robust human safety trials. Animal models (specifically rat studies) have demonstrated that high doses of Fadogia can disrupt the lipid profile of cellular membranes in the liver and kidneys, indicating potential cytotoxicity.
- Renal Impact: Elevated markers of kidney stress observed in rodent models.
- Hepatic Strain: Potential for lipid peroxidation in liver tissue.
- Testicular Integrity: While it boosts testosterone, extremely high doses showed signs of testicular tissue disruption in animal studies.
Risk Mitigation Protocol
If utilizing Fadogia, strict cycling is mandatory (e.g., 3 weeks ON, 1 week OFF) to minimize organ stress. Blood work monitoring liver enzymes (ALT/AST) is strongly recommended.
Clinical Context
This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.
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