Hormonal Balance Protocols
Hormonal optimization is not about maximizing one hormone. It is about the ratios — testosterone to cortisol, estrogen to progesterone, free versus bound fractions.
Mechanism Overview
The hormonal cascade originates in the hypothalamus (GnRH) → pituitary (LH/FSH) → gonads (testosterone/estrogen production). Interventions can target any step in this pathway. SHBG reduction, aromatase modulation, and cortisol management are the three primary levers.
Recommended Foundation Stack
Male hormonal foundation: Zinc Picolinate (30mg with dinner) + Boron (6mg morning, cycled 2 weeks on/1 off) + Tongkat Ali (400mg morning, 5 days on/2 off). Female hormonal foundation: Myo-Inositol (2g morning + 2g night) + Iodine/Kelp (150mcg morning) + Magnesium (400mg night).
Essential bloodwork: Total T, Free T (direct), SHBG, Estradiol (E2), DHEA-S, Cortisol AM. Without this baseline, supplementation is guesswork.
All Protocols — Ranked by Efficacy Score
Frequently Asked Questions
Does Tongkat Ali actually increase testosterone?
Clinical evidence supports Tongkat Ali standardized to ≥1% Eurycomanone for increasing free testosterone via LH stimulation and SHBG reduction. Ratio extracts (200:1) without standardization have no clinical basis.
What is Myo-Inositol used for in women?
Myo-Inositol improves insulin signaling in ovarian cells, making it the primary evidence-based supplement for PCOS. It also supports FSH sensitivity and regular menstrual cycling.
Should I take Boron continuously?
No. Continuous Boron use beyond 2 weeks can cause estrogen rebound via aromatase upregulation. The 2 weeks ON / 1 week OFF cycle prevents this.
Other Goal Protocols
* Clinical protocols are for educational purposes only. ChemGrade does not provide medical advice. Consult a physician before beginning any supplementation protocol.