Longevity Protocols
Longevity supplementation targets the four primary aging mechanisms: mitochondrial dysfunction, NAD+ decline, chronic inflammation, and loss of proteostasis.
Mechanism Overview
NAD+ is the master coenzyme for mitochondrial energy production and DNA repair (via Sirtuins and PARP enzymes). It declines ~50% by age 50. Omega-3 fatty acids reduce chronic inflammatory signaling (prostaglandins). Collagen supplements address declining ECM integrity.
Recommended Foundation Stack
Longevity foundation: NMN 500mg sublingual (morning) + Omega-3 2g EPA/DHA (with dinner) + Collagen 10-20g (morning, female-focus). This addresses NAD+ replenishment, inflammatory modulation, and structural protein synthesis simultaneously.
Track: biological age (epigenetic clock tests), fasting insulin, hsCRP (inflammation marker), omega-3 index (target >8%).
All Protocols — Ranked by Efficacy Score
Frequently Asked Questions
Does NMN actually work for anti-aging?
NMN is a direct NAD+ precursor. Human trials (Sinclair lab, Washington University) confirm it raises NAD+ levels significantly. Whether this translates to measurable lifespan extension in humans remains under study, but the mechanism is solid and the safety profile is excellent.
How much Omega-3 do I need?
The clinical target for anti-inflammatory benefit and cardiovascular protection is an Omega-3 Index of >8% (EPA+DHA as % of red blood cell fatty acids). This typically requires 2-4g EPA/DHA daily depending on baseline diet.
Is Collagen supplementation evidence-based?
Hydrolyzed collagen peptides have clinical evidence for improving skin elasticity, joint pain (specifically Type II collagen for cartilage), and bone density. The effect is strongest when taken with Vitamin C, which is a required cofactor for collagen synthesis.
Other Goal Protocols
* Clinical protocols are for educational purposes only. ChemGrade does not provide medical advice. Consult a physician before beginning any supplementation protocol.