SHBG Binding Affinity Inhibitors

The "Locked" Androgen Problem

Sex Hormone Binding Globulin (SHBG) is a glycoprotein that binds to testosterone with high affinity, rendering it metabolically inactive. As men age, SHBG levels naturally rise, "locking up" more testosterone. This explains why an older male might have decent Total T levels but suffer from symptoms of low T (low libido, muscle loss).

Mechanism: Ligand Displacement

Certain compounds possess a high binding affinity for SHBG. When introduced into the bloodstream, they bind to SHBG, effectively "taking the seat" that testosterone would have occupied. This displaces the testosterone, leaving it in its Free (Unbound) state.

Stinging Nettle Root (Urtica dioica)

Specifically the root extract (not the leaf) contains lignans (such as 3,4-divanillyltetrahydrofuran) that bind to SHBG. While it does not increase Total T production, it significantly alters the ratio of Free-to-Total testosterone.