LONGEVITYCELLULARMITOCHONDRIA
NAD+ Safety: NMN vs. NR
2025-02-18//READ: 6 MIN//BY CHEMGRADE RESEARCH
The Cellular Battery
NAD+ (Nicotinamide Adenine Dinucleotide) is required for sirtuin activation and DNA repair. Levels decline by ~50% by age 50. Supplementing NAD+ directly is ineffective as the molecule is too large to enter cells. We must use precursors.
NMN vs. NR
- NR (Nicotinamide Riboside): Has more human safety data. Entering the cell, it must convert to NMN before becoming NAD+.
- NMN (Nicotinamide Mononucleotide): One step closer to NAD+. Recent discovery of the "Slc12a8" transporter suggests NMN can enter cells directly, potentially making it faster acting.
The Methyl Trap
Metabolizing high doses of NMN/NR requires methyl groups (TMG). If you take precursors without TMG, you risk depleting your methyl pool, leading to fatigue. Always stack NAD+ boosters with TMG (Trimethylglycine).
* This analysis is for educational purposes only. ChemGrade does not provide medical advice.
Clinical Context
This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.
View Protocol