Estrogen Dominance Clearance Protocols

The Detoxification Pipeline

"Estrogen Dominance" often stems from poor elimination, not overproduction. The body must metabolize used estrogen via the liver (Phase I) and excrete it via the gut (Phase II). If either step is blocked, estrogen recirculates, causing bloating, mood swings, and breast tenderness.

Phase I: DIM (The Converter)

DIM (Diindolylmethane) pushes estrogen down the healthy 2-hydroxy pathway, preventing it from turning into the potent/pro-cancer 16-hydroxy metabolites. Think of DIM as the traffic cop directing estrogen to the correct exit.

Phase II: Calcium D-Glucarate (The Excretor)

Once the liver packages estrogen for removal (Glucuronidation), it enters the gut. However, an enzyme called Beta-Glucuronidase can "unpack" it, allowing it to be reabsorbed into the blood. Calcium D-Glucarate inhibits this enzyme, ensuring the packaged estrogen stays in the stool and leaves the body.