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Glutathione Recycling Cofactors

2025-02-19//READ: 4 MIN//BY CHEMGRADE RESEARCH

The Oral Absorption Failure

Glutathione is the body's "Master Antioxidant," critical for liver detoxification and immune function. However, supplementing oral Reduced Glutathione is often ineffective because it is destroyed by stomach acid and enzymes (gamma-glutamyltransferase) before reaching the bloodstream.

The GlyNAC Protocol

Instead of taking the finished molecule, you must provide the raw materials for your cells to build it themselves. Glutathione is a tripeptide made of Cysteine, Glycine, and Glutamate.

  • NAC (N-Acetyl-Cysteine): Provides Cysteine, the rate-limiting amino acid.
  • Glycine: Often the forgotten bottleneck in modern diets low in collagen/connective tissue.
Recent trials show that the combination of NAC + Glycine ("GlyNAC") restores cellular glutathione levels in older adults to that of youth.

ChemGrade Verdict

Skip the expensive Liposomal Glutathione. Take 600mg NAC + 2g Glycine daily. It is cheaper and chemically superior for intracellular synthesis.

* This analysis is for educational purposes only. ChemGrade does not provide medical advice.

Clinical Context

This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.

View Protocol