CHEMGRADE
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PROTOCOLXY-OPTIMIZATIONSHBG

Boron Cycling for Estrogen Management

2025-02-05//READ: 3 MIN//BY CHEMGRADE RESEARCH

SHBG Suppression

Boron is a trace mineral that significantly impacts steroid hormone usage. Clinical data (Naghii et al.) demonstrated that 10mg of Boron daily reduced Sex Hormone Binding Globulin (SHBG) by significantly increasing Free Testosterone levels within just 7 days.

Why Cycling is Mandatory

While Boron initially boosts Free T by lowering SHBG, prolonged continuous use (4+ weeks) can lead to a paradoxical increase in Estradiol (E2). The body attempts to balance the freed testosterone by aromatizing it into estrogen. To prevent this "Estrogen Creep," Boron must be cycled.

The 2-Week Protocol

The optimal rhythm allows for SHBG suppression without triggering significant aromatase upregulation.

Cycle Schedule

ON: 14 Days (6mg - 10mg daily)
OFF: 7 Days (Zero intake)
Repeat indefinitely.

* This analysis is for educational purposes only. ChemGrade does not provide medical advice.

Clinical Context

This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.

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