Tongkat Ali: Standardisation de l'Eurycomanone
Executive Summary
Tongkat Ali (Eurycoma longifolia) is one of the few herbal compounds with human clinical data supporting testosterone enhancement. However, the market is flooded with "ratio extracts" (e.g., 200:1) that lack bioactive verification. For efficacy, users must seek standardized Eurycomanone content.
Mechanism of Action
The primary bioactive peptide, Eurycomanone, signals the hypothalamus to release Luteinizing Hormone (LH). This LH travels to the Leydig cells in the testes, stimulating endogenous testosterone production. Additionally, it has been shown to reduce the conversion of testosterone to estrogen (aromatase inhibition).
The "Ratio" Deception
A "200:1" extract claims that 200kg of root was used to make 1kg of powder. There is no regulatory body verifying this. It is often a marketing tactic to sell root dust. Clinical trials utilize extracts standardized to 1.5% - 2.0% Eurycomanone.
ChemGrade Verdict
Ignore ratios. Look for the HPLC Analysis on the label. If it does not state "Standardized to >1% Eurycomanone," it is likely inert.
Clinical Context
This compound is frequently utilized in the Sleep Optimization and Cortisol Management protocols.
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