Inositol Protocols for Insulin Sensitivity

The Insulin-Ovarian Connection

In conditions like PCOS, cellular insulin resistance leads to compensatory hyperinsulinemia (high blood insulin). High insulin directly stimulates the ovaries to overproduce androgens (testosterone), causing acne, hair loss, and anovulation. Treating the insulin resistance treats the root cause.

Mechanism: The Second Messenger

Inositols are sugar alcohols that act as second messengers for insulin signaling. They tell the cell to open the door for glucose.

• Myo-Inositol (MI): Mediates glucose uptake and FSH signaling (egg quality).
• D-Chiro-Inositol (DCI): Mediates glycogen synthesis and androgen synthesis.

The Critical 40:1 Ratio

Healthy plasma maintains a 40:1 ratio of MI to DCI. Taking random "Inositol" blends can backfire. Too much DCI can actually worsen egg quality. You must seek the physiological 40:1 ratio.